Role of Hypomagnesaemia in Acute Kidney Injury

Different Biomarkers of Acute kidney Injury in Cancer Patients

Acute Kidney Injury (AKI) occurs if the kidneys suddenly lose their ability to remove waste products. When the kidneys lose their ability to filter, dangerous levels of waste products can accumulate, which can upset the chemical composition of the blood and urine. Chemotherapy is one of the methods used to treat or temporarily reduce cancer by using certain medications. The main task of this tr...

Protective role of Zataria multiflora on cisplatin-induced acute kidney injury

Background and objectives: Cisplatin (CP), as an anticancer drug, causes nephrotoxicity. Zataria multiflora Boiss. (ZM), a plant which has been used as a herbal medicine for a variety of ailments. Our study aimed to examine the effects of ZM on cisplatin induced nephrotoxicity. Methods: Thirty-two male mice were randomly divided into four groups. The co...

The Preventive Role of Pioglitazone in Glycerol-Induced Acute Kidney Injury in Rats during Two Different Treatment Periods

Background: Acute kidney injury is the most life-threatening complication of rhabdomyolysis. Glycerol is commonly used to induce this injury. The aim was to investigate the renoprotective effects of pioglitazone and the possible advantage of administering the drug for a longer period.Methods: Twenty-four male Albino Wistar rats were randomly divided into 4 groups (n=6/group): (A) control, (B) g...

Role of leukocytes in the pathogenesis of acute kidney injury

Role of Hypoxia-Inducible Factors in Acute Kidney Injury

Oxygen is vital to mammalian survival. Oxygen deprivation, defined as hypoxia, elicits adaptive responses in cells and tissues, a process regulated by proteins known as hypoxia-inducible factors (HIF). Animal studies have provided compelling data to demonstrate a pivotal role for the HIF pathway in the pathogenesis of acute kidney injury (AKI) that have led to initial human clinical trials exam...